The Collaborative Study on the Genetics of Alcoholism: Overview
Ethanol is converted to acetaldehyde by alcohol dehydrogenase (ADH) and subsequently to acetate by aldehyde dehydrogenase (ALDH). Acetate is conjugated to coenzyme A and the result
The Genetics of Alcohol Metabolism: Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Variants
Examples of genes that have been shown to influence vulnerability to alcoholism and related phenotypes are also discussed. Genes may interact with specific toxic environments, such